FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG
Gene Variant Detail

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Gene FLT3
Variant G613_K614insYVDFREYEYDLKWEFRPRENLEFG
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG (F612_G613insGYVDFREYEYDLKWEFRPRENLEF) results in the insertion of 24 amino acids in the protein kinase domain of the Flt3 protein between amino acids 613 and 614 (UniProt.org). G613_K614insYVDFREYEYDLKWEFRPRENLEFG results in transformation of cultured cells (PMID: 11756186), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG

FLT3 mutant FLT3 act mut FLT3 exon 15 ins FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG

FLT3 mutant FLT3 exon15 FLT3 exon 15 ins FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG

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Transcript NM_004119.3
gDNA chr13:g.28033989_28033990insACCAAACTCAAGGTTCTCCCTAGGCCTAAACTCCCACTTAAGGTCATACTCATACTCCCTAAAGTCTACATA
cDNA c.1839_1840insTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAGTTTAGGCCTAGGGAGAACCTTGAGTTTGGT
Protein p.G613_K614insYVDFREYEYDLKWEFRPRENLEFG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28033989_28033990insACCAAACTCAAGGTTCTCCCTAGGCCTAAACTCCCACTTAAGGTCATACTCATACTCCCTAAAGTCTACATA c.1839_1840insTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAGTTTAGGCCTAGGGAGAACCTTGAGTTTGGT p.G613_K614insYVDFREYEYDLKWEFRPRENLEFG RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28033989_28033990insACCAAACTCAAGGTTCTCCCTAGGCCTAAACTCCCACTTAAGGTCATACTCATACTCCCTAAAGTCTACATA c.1839_1840insTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAGTTTAGGCCTAGGGAGAACCTTGAGTTTGGT p.G613_K614insYVDFREYEYDLKWEFRPRENLEFG RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG acute myeloid leukemia sensitive Tandutinib Preclinical - Cell culture Actionable In a preclinical study, Tandutinib (CT53518) inhibited proliferation of cells expressing FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG in culture (PMID: 12124172). 12124172