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Therapy Name	Tandutinib
Synonyms
Therapy Description	Tandutinib (CT53518) is a tyrosine kinase inhibitor of FLT3, KIT, and PDGFRbeta, which inhibits cell proliferation and induces apoptosis (PMID: 12166950, PMID: 12124172, PMID: 27663390).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Tandutinib		MLN518\|CT53518\|CT-53518\|MLN-518	FLT3 Inhibitor 69 KIT Inhibitor 57 PDGFR-beta Inhibitor 14	Tandutinib (CT53518) is a tyrosine kinase inhibitor of FLT3, KIT, and PDGFRbeta, which inhibits cell proliferation and induces apoptosis (PMID: 12166950, PMID: 12124172, PMID: 27663390).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	Tandutinib	Preclinical - Cell culture	Actionable	In a preclinical study, Tandutinib (CT53518) treatment inhibited viability of an acute myeloid leukemia cell line harboring FLT3 internal tandem duplication (ITD) in culture (PMID: 31751472).	31751472
FLT3 exon 14 ins FLT3 D835Y	acute myeloid leukemia	resistant	Tandutinib	Preclinical - Cell culture	Actionable	In a preclinical study, an acute myeloid cell line harboring FLT3 internal tandem duplication (ITD) and FLT3 D835Y demonstrated resistance to Tandutinib (CT53518) treatment in culture (PMID: 31751472).	31751472
FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG	acute myeloid leukemia	sensitive	Tandutinib	Preclinical - Cell culture	Actionable	In a preclinical study, Tandutinib (CT53518) inhibited proliferation of cells expressing FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG in culture (PMID: 12124172).	12124172
FLT3 I836del	cancer	sensitive	Tandutinib	Preclinical - Cell culture	Actionable	In a preclinical study, Tandutinib (CT53518) inhibited phosphorylation of FLT3 and activation of ERK and STAT5, and reduced growth of transformed cells expressing FLT3 I836del in culture (PMID: 15256420).	15256420
FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL	acute myeloid leukemia	sensitive	Tandutinib	Preclinical - Cell culture	Actionable	In a preclinical study, tandutinib (CT53518) inhibited proliferation of cells expressing FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL in culture (PMID: 12124172).	12124172
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE	acute myeloid leukemia	sensitive	Tandutinib	Preclinical	Actionable	In a preclinical study, tandutinib (CT53518) inhibited proliferation of cells expressing FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE in culture (PMID: 12124172).	12124172
FLT3 R595_L601dup	acute myeloid leukemia	sensitive	Tandutinib	Preclinical	Actionable	In a preclinical study, tandutinib (CT53518) inhibited cell proliferation in cell culture and in mouse models carrying FLT3 L601_K602insREYEYDL (PMID: 12124172).	12124172
FLT3 Y599_D600insGLYVDFREYEY	acute myeloid leukemia	sensitive	Tandutinib	Preclinical	Actionable	In a preclinical study, tandutinib (CT53518) inhibited proliferation of cells expressing FLT3 Y599_D600insGLYVDFREYEY in culture (PMID: 12124172).	12124172

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