ALK S1206R
Gene Variant Detail

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Gene ALK
Variant S1206R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK S1206R lies within the protein kinase domain of the Alk protein (UniProt.org). S1206R has been demonstrated to occur as a secondary drug resistance mutation in the context of EML4-ALK (PMID: 22034911), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK S1206R

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Transcript NM_004304.5
gDNA chr2:g.29220734_29220735delTCinsCG
cDNA c.3616_3617delTCinsCG
Protein p.S1206R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220734_29220735delTCinsCG c.3616_3617delTCinsCG p.S1206R RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220734_29220735delTCinsCG c.3616_3617delTCinsCG p.S1206R RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK S1206R Advanced Solid Tumor predicted - sensitive TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, TPX-0131 inhibited kinase activity of ALK S1206R in an in vitro assay (PMID: 34158340). 34158340