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Gene ALK
Variant S1206R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK S1206R lies within the protein kinase domain of the Alk protein (UniProt.org). S1206R has been demonstrated to occur as a secondary drug resistance mutation in the context of EML4-ALK (PMID: 22034911), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK S1206R

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Transcript NM_004304.5
gDNA chr2:g.29220734_29220735delTCinsCG
cDNA c.3616_3617delTCinsCG
Protein p.S1206R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220734_29220735delTCinsCG c.3616_3617delTCinsCG p.S1206R RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220734_29220735delTCinsCG c.3616_3617delTCinsCG p.S1206R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries