ALK S1206R
Gene Variant Detail

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Gene ALK
Variant S1206R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK S1206R lies within the protein kinase domain of the Alk protein (UniProt.org). S1206R has been demonstrated to occur as a secondary drug resistance mutation in the context of EML4-ALK (PMID: 22034911), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK S1206R

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Transcript NM_004304.5
gDNA chr2:g.29220734_29220735delTCinsCG
cDNA c.3616_3617delTCinsCG
Protein p.S1206R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29220734_29220735delTCinsCG c.3616_3617delTCinsCG p.S1206R RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220734_29220735delTCinsCG c.3616_3617delTCinsCG p.S1206R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK S1206R unknown
EML4 - ALK ALK S1206R