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Gene BRAF
Variant R682W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF R682W lies within the protein kinase domain of the Braf protein (UniProt.org). R682W has been demonstrated to confer resistance to an EGFR inhibitor in the context of EGFR exon 19 deletions in cultured cells (PMID: 27478040), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, May 2024).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF R682W

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Transcript NM_004333.6
gDNA chr7:g.140739895G>A
cDNA c.2044C>T
Protein p.R682W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140739827_140739829delAGAinsTGG c.2044_2046delAGAinsTGG p.R682W RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140734741_140734743delCGCinsTGG c.2044_2046delCGCinsTGG p.R682W RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries