Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | BRAF |
Variant | I463W |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | BRAF I463W lies within the protein kinase domain of the Braf protein (UniProt.org). I463W has been demonstrated to confer resistance to some Braf inhibitors in culture (PMID: 31925410), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, May 2024). |
Associated Drug Resistance | Y |
Category Variants Paths |
BRAF mutant BRAF I463X BRAF I463W |
Transcript | NM_004333.6 |
gDNA | chr7:g.140781619_140781621delATTinsTGG |
cDNA | c.1387_1389delATTinsTGG |
Protein | p.I463W |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001354609.1 | chr7:g.140781619_140781621delATTinsTGG | c.1387_1389delATTinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
NM_001378468.1 | chr7:g.140781619_140781621delATTinsTGG | c.1387_1389delATTinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
NM_001378475.1 | chr7:g.140776953_140776955delATCinsTGG | c.1387_1389delATCinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
NM_004333.6 | chr7:g.140781619_140781621delATTinsTGG | c.1387_1389delATTinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
NM_001354609.2 | chr7:g.140781619_140781621delATTinsTGG | c.1387_1389delATTinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
NM_001378474.1 | chr7:g.140781619_140781621delATTinsTGG | c.1387_1389delATTinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
NM_004333.5 | chr7:g.140781619_140781621delATTinsTGG | c.1387_1389delATTinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
XM_047420769.1 | chr7:g.140781619_140781621delATTinsTGG | c.1387_1389delATTinsTGG | p.I463W | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|