BRAF I463W
Gene Variant Detail

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Gene BRAF
Variant I463W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF I463W lies within the protein kinase domain of the Braf protein (UniProt.org). I463W has been demonstrated to confer resistance to some Braf inhibitors in culture (PMID: 31925410), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Mar 2025).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF I463X BRAF I463W

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Transcript NM_004333.6
gDNA chr7:g.140781619_140781621delATTinsTGG
cDNA c.1387_1389delATTinsTGG
Protein p.I463W
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.