ABL1 T315R
Gene Variant Detail

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Gene ABL1
Variant T315R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ABL1 T315R lies within the protein kinase domain of the Abl1 protein (UniProt.org). T315R is associated with Abl1 inhibitor resistance in the context of BCR-ABL1 (PMID: 26511402), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 T315R

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Transcript NM_005157.6
gDNA chr9:g.130872896_130872897delCTinsGG
cDNA c.944_945delCTinsGG
Protein p.T315R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.5 chr9:g.130872896_130872897delCTinsGG c.944_945delCTinsGG p.T315R RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130872896_130872897delCTinsGG c.944_945delCTinsGG p.T315R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References