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Gene ABL1
Variant T315Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ABL1 T315Y lies within the protein kinase domain of the Abl1 protein (UniProt.org). T315Y is associated with Abl1 inhibitor resistance in the context of BCR-ABL1 (PMID: 26511402), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 T315Y

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Transcript NM_005157.6
gDNA chr9:g.130872895_130872896delACinsTA
cDNA c.943_944delACinsTA
Protein p.T315Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.5 chr9:g.130872895_130872896delACinsTA c.943_944delACinsTA p.T315Y RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130872895_130872896delACinsTA c.943_944delACinsTA p.T315Y RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries