FBXW7 L443F
Gene Variant Detail

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Gene FBXW7
Variant L443F
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions FBXW7 L443F lies within WD repeat 2 of the Fbxw7 protein (UniProt.org). L443F induces degradation of Mcl-1 and Braf similar to wild-type Fbxw7 in culture but fails to induce Cyclin E degradation (PMID: 32907612), results in a loss of NICD degradation leading to increased Notch transcriptional activity in a reporter assay (PMID: 27247421), and decreased binding, ubiquitination, and degradation of Mlst8 in culture (PMID: 34741373).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 L443F

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Transcript NM_001349798.2
gDNA chr4:g.152328299G>A
cDNA c.1327C>T
Protein p.L443F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024454121.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152328299G>A c.1327C>T p.L443F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FBXW7 inact mut hematologic cancer sensitive REC-2282 Preclinical Actionable In a preclinical study, REC-2282 (AR-42) inhibited human hematologic cancer cell lines harboring FBXW7 inactivating mutations in culture (PMID: 23274910). 23274910
FBXW7 inact mut hematologic cancer sensitive Entinostat Preclinical Actionable In a preclinical study, entinostat (MS-275) inhibited cancer cells from advanced solid tumors and hematological cells harboring FBXW7 inactivating mutations in culture (PMID: 23274910). 23274910
FBXW7 inact mut Advanced Solid Tumor sensitive REC-2282 Preclinical Actionable In a preclinical study, REC-2282 (AR-42) inhibited human cancer cell lines harboring FBXW7 inactivating mutations in culture (PMID: 23274910). 23274910
FBXW7 inact mut breast cancer sensitive Sirolimus Preclinical - Cell line xenograft Actionable In a preclinical study, breast cancer cells harboring a FBXW7 mutation demonstrated sensitivity to Rapamune (sirolimus) in culture and in cell line xenograft models (PMID: 18787170). 18787170
FBXW7 inact mut Advanced Solid Tumor sensitive Entinostat Preclinical Actionable In a preclinical study, entinostat (MS-275) inhibited cancer cells from advanced solid tumors and hematological cells harboring FBXW7 inactivating mutations in culture (PMID: 23274910). 23274910
FBXW7 inact mut hematologic cancer sensitive Belinostat Preclinical Actionable In a preclinical study, Beleodaq (belinostat) inhibited human hematologic cancer cell lines harboring FBXW7 inactivating mutations in culture (PMID: 23274910). 23274910
FBXW7 inact mut Advanced Solid Tumor sensitive Belinostat Preclinical Actionable In a preclinical study, Beleodaq (belinostat) inhibited human cancer cell lines harboring FBXW7 inactivating mutations in culture (PMID: 23274910). 23274910
FBXW7 inact mut Advanced Solid Tumor resistant Docetaxel Preclinical Actionable In a preclinical study, human cancer cell lines harboring FBXW7 inactivating mutations were resistant to docetaxel in culture (PMID: 23274910). 23274910
FBXW7 inact mut endometrial cancer predicted - sensitive RP-3500 + RP-6306 Phase I Actionable In a Phase I trial (MYTHIC), treatment with the combination of RP-6306 and RP-3500 in ovarian or endometrial cancer patients harboring CCNE1 amplification, FBXW7 mutations, and/or PPP2R1A mutations resulted in a clinical benefit rate (CBR) of 79%, a median progression-free survival (mPFS) of 21 weeks, and a response rate of 38% in ovarian cancer (n=24), and a CBR of 48%, mPFS of 17 weeks, and a response rate of 26% in endometrial cancer (n=27) (Cancer Res (2025) 85 (8_Supplement_2): CT262; NCT04855656). detail...
FBXW7 mutant Her2-receptor negative breast cancer predicted - sensitive LY3039478 Case Reports/Case Series Actionable In a Phase I trial, LY3039478 treatment resulted in partial response lasted 9.5 months in a patient with hormone receptor-positive, Erbb2 (Her2)-negative breast cancer harboring FBXW7 mutation (PMID: 30060061; NCT01695005). 30060061