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Therapy Name	Entinostat
Synonyms
Therapy Description	Entinostat (MS-275) inhibits HDAC activity, with selectivity towards HDAC1, 2, and 3, which results in increased histone acetylation, and potentially leads to decreased tumor cell proliferation and tumor growth (PMID: 19724929, PMID: 17383217, PMID: 32503469).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Entinostat		HDAC inhibitor SNDX-275\|MS 275	HDAC Inhibitor 45	Entinostat (MS-275) inhibits HDAC activity, with selectivity towards HDAC1, 2, and 3, which results in increased histone acetylation, and potentially leads to decreased tumor cell proliferation and tumor growth (PMID: 19724929, PMID: 17383217, PMID: 32503469).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
RB1 loss	retinoblastoma	sensitive	Entinostat	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Entinostat (MS-275) inhibited growth of retinoblastoma cell lines in culture and inhibited tumor growth in a retinoblastoma cell line xenograft model (PMID: 18483379), which have been demonstrated to be deficient in RB1 (PMID: 23498719).	23498719 18483379
FBXW7 inact mut	Advanced Solid Tumor	sensitive	Entinostat	Preclinical	Actionable	In a preclinical study, entinostat (MS-275) inhibited cancer cells from advanced solid tumors and hematological cells harboring FBXW7 inactivating mutations in culture (PMID: 23274910).	23274910
FBXW7 inact mut	hematologic cancer	sensitive	Entinostat	Preclinical	Actionable	In a preclinical study, entinostat (MS-275) inhibited cancer cells from advanced solid tumors and hematological cells harboring FBXW7 inactivating mutations in culture (PMID: 23274910).	23274910

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT01038778	Phase Ib/II	Entinostat Aldesleukin	Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer	Active, not recruiting	USA	0
NCT01928576	Phase II	Nivolumab Entinostat Azacitidine	Phase II Anti-PD1 Epigenetic Priming Study in NSCLC.	Completed	USA	0
NCT02780804	Phase I	Entinostat	Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors	Completed	USA	0
NCT02897778	Phase I	Entinostat	Cardiac Safety Study of Entinostat in Men and Women With Advanced Solid Tumors	Completed	USA	0
NCT03211988	Phase II	Entinostat	Entinostat Neuroendocrine (NE) Tumor	Terminated	USA	0
NCT03361800	Phase I	Entinostat	Window of Opportunity Trial of Entinostat in Patients With Newly Diagnosed Stage I-IIIC,TNBC	Terminated	USA	0
NCT03924245	Phase Ib/II	Entinostat Entinostat + Olaparib	Olaparib and Entinostat in Patients With Recurrent, Platinum-Refractory, Resistant Ovarian, Primary Peritoneal, Fallopian Tube Cancers	Terminated	USA	0

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