ALK Q1188_L1190del
Gene Variant Detail

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Gene ALK
Variant Q1188_L1190del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions ALK Q1188_L1190del results in the deletion of three amino acids in the protein kinase domain of the Alk protein from amino acids 1188 to 1190 (UniProt.org). Q1188_L1190del has been identified in the scientific literature (PMID: 33887694, PMID: 37304651), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK Q1188_L1190del

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Transcript NM_004304.5
gDNA chr2:g.29220785_29220793delGATTGCAGG
cDNA c.3563_3571delAATCCCTGC
Protein p.Q1188_L1190del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29220785_29220793delGATTGCAGG c.3563_3571delAATCCCTGC p.Q1188_L1190del RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220785_29220793delGATTGCAGG c.3563_3571delAATCCCTGC p.Q1188_L1190del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References