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Gene MAP2K1
Variant I139G
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 I139G lies within the protein kinase domain of the Map2k1 protein (UniProt.org). I139G is predicted to have no effect on Map2k1 protein function as demonstrated by basal kinase activity similar to wild-type Map2k1 in an in vitro assay, and is associated with resistance to Mek inhibition (PMID: 12370306).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 I139G

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Transcript NM_002755.4
gDNA chr15:g.66436869_66436870delATinsGG
cDNA c.415_416delATinsGG
Protein p.I139G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.4 chr15:g.66436869_66436870delATinsGG c.415_416delATinsGG p.I139G RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66443322_66443323delATinsGG c.415_416delATinsGG p.I139G RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436869_66436870delATinsGG c.415_416delATinsGG p.I139G RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436869_66436870delATinsGG c.415_416delATinsGG p.I139G RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436869_66436870delATinsGG c.415_416delATinsGG p.I139G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 I139G Advanced Solid Tumor predicted - resistant CI-1040 Preclinical - Biochemical Actionable In a preclinical study, CI-1040 (PD184352) did not inhibit kinase activity of MAP2K1 I139G in an in vitro assay (PMID: 12370306). 12370306