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Gene MAP2K1
Variant I139R
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 I139R lies within the protein kinase domain of the Map2k1 protein (UniProt.org). I139R is predicted to have no effect on Map2k1 protein function as demonstrated by basal kinase activity similar to wild-type Map2k1 in an in vitro assay, and is associated with decreased sensitivity to Mek inhibition (PMID: 12370306).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 I139R

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Transcript NM_002755.4
gDNA chr15:g.66436870_66436871delTCinsGG
cDNA c.416_417delTCinsGG
Protein p.I139R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.3 chr15:g.66436870_66436871delTCinsGG c.416_417delTCinsGG p.I139R RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66443323_66443324delTTinsGG c.416_417delTTinsGG p.I139R RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436870_66436871delTCinsGG c.416_417delTCinsGG p.I139R RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436870_66436871delTCinsGG c.416_417delTCinsGG p.I139R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 I139R Advanced Solid Tumor decreased response CI-1040 Preclinical - Biochemical Actionable In a preclinical study, MAP2K1 I139R demonstrated decreased sensitivity to CI-1040 (PD184352) in an in vitro kinase assay (PMID: 12370306). 12370306