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Gene MAP2K1
Variant L118P
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions MAP2K1 L118P lies within the protein kinase domain of the Map2k1 protein (UniProt.org). L118P is associated with MEK inhibitor resistance and results in decreased basal kinase activity in an in vitro assay (PMID: 12370306), and therefore, its predicted to lead to a loss of Map2k1 protein function.
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 inact mut MAP2K1 L118P

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Transcript NM_002755.4
gDNA chr15:g.66436807T>C
cDNA c.353T>C
Protein p.L118P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.3 chr15:g.66436807T>C c.353T>C p.L118P RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436807T>C c.353T>C p.L118P RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436807T>C c.353T>C p.L118P RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436807T>C c.353T>C p.L118P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 L118P Advanced Solid Tumor predicted - resistant CI-1040 Preclinical - Biochemical Actionable In a preclinical study, CI-1040 (PD184352) did not inhibit kinase activity of MAP2K1 L118P in an in vitro assay (PMID: 12370306). 12370306