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Gene ARID2
Variant S218Pfs*74
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ARID2 S218Pfs*74 indicates a shift in the reading frame starting at amino acid 218 and terminating 74 residues downstream causing a premature truncation of the 1835 amino acid Arid2 protein (UniProt.org). Due to the loss of the C2H2-type zinc finger domain (PMID: 32071245), S218Pfs*74 is predicted to lead to a loss of Arid2 protein function.
Associated Drug Resistance
Category Variants Paths

ARID2 mutant ARID2 inact mut ARID2 S218Pfs*74

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Transcript NM_152641.4
gDNA chr12:g.45821434delT
cDNA c.652delT
Protein p.S218Pfs*74
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_152641.4 chr12:g.45821434delT c.652delT p.S218Pfs*74 RefSeq GRCh38/hg38
XM_006719272.4 chr12:g.45821434delT c.652delT p.S218Pfs*74 RefSeq GRCh38/hg38
NM_001347839.2 chr12:g.45821434delT c.652delT p.S218Pfs*74 RefSeq GRCh38/hg38
XM_047428489.1 chr12:g.45821434delT c.652delT p.S218Pfs*74 RefSeq GRCh38/hg38
NM_001347839.1 chr12:g.45821434delT c.652delT p.S218Pfs*74 RefSeq GRCh38/hg38
NM_152641.3 chr12:g.45821434delT c.652delT p.S218Pfs*74 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ARID2 S218Pfs*74 loss of function - predicted