MAP2K1 I141S
Gene Variant Detail

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Gene MAP2K1
Variant I141S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MAP2K1 I141S lies within the protein kinase domain of the Map2k1 protein (UniProt.org). I141S has been demonstrated to confer resistance to Braf inhibitors in the context of BRAF G469V (PMID: 34737188), but has not been biochemically characterized and therefore, its effect on Map2k1 protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 I141S

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Transcript NM_002755.4
gDNA chr15:g.66436876T>G
cDNA c.422T>G
Protein p.I141S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.3 chr15:g.66436876T>G c.422T>G p.I141S RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436876T>G c.422T>G p.I141S RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436876T>G c.422T>G p.I141S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
MAP2K1 I141S unknown