Gene Variant Detail

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Gene ALK
Variant A1252V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions ALK A1252V lies within the protein kinase domain of the Alk protein (UniProt.org). A1252V does not result in Alk autophosphorylation and is not transforming in culture (PMID: 22086496), and therefore, is predicted to have no effect on Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK A1252V

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Transcript NM_004304.5
gDNA chr2:g.29209867G>A
cDNA c.3755C>T
Protein p.A1252V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29209867G>A c.3755C>T p.A1252V RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29209867G>A c.3755C>T p.A1252V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK A1252V no effect - predicted