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Gene ALK
Variant C1021V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions ALK C1021V lies within the extracellular domain of the Alk protein (UniProt.org). C1021V does not result in Alk autophosphorylation and is not transforming in culture (PMID: 22086496), and therefore, is predicted to have no effect on Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK C1021V

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Transcript NM_004304.5
gDNA chr2:g.29226927_29226928delTGinsGT
cDNA c.3061_3062delTGinsGT
Protein p.C1021V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29226927_29226928delTGinsGT c.3061_3062delTGinsGT p.C1021V RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29226927_29226928delTGinsGT c.3061_3062delTGinsGT p.C1021V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References