ALK T535N
Gene Variant Detail

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Gene ALK
Variant T535N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK T535N lies within MAM domain 2 of the Alk protein (UniProt.org). T535N has been identified in sequencing studies (PMID: 34465320), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK T535N

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Transcript NM_004304.5
gDNA chr2:g.29318347G>T
cDNA c.1604C>A
Protein p.T535N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29318347G>T c.1604C>A p.T535N RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29318347G>T c.1604C>A p.T535N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References