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Gene RET
Variant Y1062F
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET Y1062F lies within the cytoplasmic domain of the Ret protein (UniProt.org). Y1062F results in reduced phosphorylation of Ret and Erk (PMID: 26395553), decreased binding to Frs2 and Shc in cell culture (PMID: 11360177), decreased binding to Pkca and reduced activation of Pkc (PMID: 12771945), Mapk7 (Bmk1) (PMID: 11237712), and Rap1 in cell culture (PMID: 17210721), decreased PI3K/Akt and Mapk signaling in the context of RET C634Y expression in cell culture (PMID: 11390647, PMID: 10919641), and reduced signaling of the Ras-Mapk pathway in a reporter assay (PMID: 32062451).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET Y1062F

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Transcript NM_020975.6
gDNA chr10:g.43126720A>T
cDNA c.3185A>T
Protein p.Y1062F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43126720A>T c.3185A>T p.Y1062F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43126720A>T c.3185A>T p.Y1062F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43126720A>T c.3185A>T p.Y1062F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43126720A>T c.3185A>T p.Y1062F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43126720A>T c.3185A>T p.Y1062F RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43126720A>T c.3185A>T p.Y1062F RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries