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Gene RET
Variant Y1062C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions RET Y1062C lies within the cytoplasmic domain of the Ret protein (UniProt.org). Y1062C results in reduced phosphorylation of Ret and Erk in cell culture (PMID: 26395553), and therefore, is predicted to lead to a loss of function of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET Y1062C

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Transcript NM_020975.6
gDNA chr10:g.43126720A>G
cDNA c.3185A>G
Protein p.Y1062C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43126720A>G c.3185A>G p.Y1062C RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43126720A>G c.3185A>G p.Y1062C RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43126720A>G c.3185A>G p.Y1062C RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43126720A>G c.3185A>G p.Y1062C RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43126720A>G c.3185A>G p.Y1062C RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43126720A>G c.3185A>G p.Y1062C RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References