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Gene RET
Variant P270L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET P270L lies within the Cadherin domain of the Ret protein (UniProt.org). P270L results in intracellular mislocalization near the endoplasmic reticulum and nucleus but phosphorylation of Ret and Erk similar to wild-type in culture (PMID: 26395553), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET P270L

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Transcript NM_020975.6
gDNA chr10:g.43105135C>T
cDNA c.809C>T
Protein p.P270L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries