Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RET
Variant P270L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET P270L lies within the Cadherin domain of the Ret protein (UniProt.org). P270L results in intracellular mislocalization near the endoplasmic reticulum and nucleus but phosphorylation of Ret and Erk similar to wild-type in culture (PMID: 26395553), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET P270L

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_020975.6
gDNA chr10:g.43105135C>T
cDNA c.809C>T
Protein p.P270L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406763.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43105135C>T c.809C>T p.P270L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References