ERBB3 E928fs
Gene Variant Detail

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Gene ERBB3
Variant E928fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ERBB3 (HER3) E928fs results in a change in the amino acid sequence of the Erbb3 (Her3) protein beginning at aa 928 of 1342, likely resulting in premature truncation of the functional protein (UniProt.org). E928fs (reported as E928fs*16) results in basal level Erbb3 (Her3) phosphorylation comparable to wild-type protein, but fails to transactivate coexpressed Erbb2 (Her2) in the presence of ligand, and is not transforming in culture (PMID: 33323455), and therefore, is predicted to lead to a loss of Erbb3 (Her3) protein function.
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 inact mut ERBB3 E928fs

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Transcript NM_001982.4
gDNA chr12:g.(56098847_56098848)
cDNA c.(2782_2781)
Protein p.E928fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982.4 chr12:g.(56098847_56098848) c.(2782_2781) p.E928fs RefSeq GRCh38/hg38
NM_001982.3 chr12:g.(56098847_56098848) c.(2782_2781) p.E928fs RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 mutant Advanced Solid Tumor no benefit Neratinib Phase II Actionable In a Phase II trial (SUMMIT), Nerlynx (neratinib) treatment resulted in no objective response, a clinical benefit rate of 12.5% (2/16), and a median progression-free survival of 1.7 months in patients with advanced solid tumors harboring ERBB3 (HER3) mutations (PMID: 29420467; NCT01953926). 29420467
ERBB3 mutant invasive bladder transitional cell carcinoma predicted - sensitive Cisplatin + Gemcitabine + Sorafenib Phase II Actionable In a Phase II trial, ERBB3 mutations were only detected in patients with muscle-invasive urothelial bladder cancer that responded to Nexavar (sorafenib), Platinol (cisplatin) and Gemzar (gemcitabine) combination therapy (J Clin Oncol 35, 2017 (suppl 6S; abstract 345)). detail...