Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene BRAF
Variant S365L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF S365L does not lie within any known functional domains of the Braf protein (UniProt.org). S365L has been demonstrated to occur as a secondary drug resistance mutation (PMID: 34178685), but has not been biochemically characterized and therefore, it's effect on Braf protein function is unknown (PubMed, May 2024).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF S365L

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_004333.6
gDNA chr7:g.140794354G>A
cDNA c.1094C>T
Protein p.S365L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017012558.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140783139_140783140delTCinsCT c.1093_1094delTCinsCT p.S365L RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140794354G>A c.1094C>T p.S365L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF S365L unknown
BRAF S365L BRAF V600E