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Gene ATM
Variant Q1919P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATM Q1919P does not lie within any known functional domains of the Atm protein (UniProt.org). Q1919P has been identified in the scientific literature (PMID: 34911817), but has not been biochemically characterized and therefore, its effect on Atm protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

ATM mutant ATM Q1919P

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Transcript NM_000051.4
gDNA chr11:g.108307978A>C
cDNA c.5756A>C
Protein p.Q1919P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011542843.3 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_017017790.3 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_011542843.2 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_011542840.4 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_017017790.2 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_047426975.1 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_047426976.1 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_006718843.4 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_006718843.5 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_005271562.6 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
NM_000051.3 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_011542840.3 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
NM_000051.4 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
NM_001351834.1 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_005271562.5 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_017017789.2 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
NM_001351834.2 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38
XM_017017791.1 chr11:g.108307978A>C c.5756A>C p.Q1919P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM Q1919P lung non-small cell carcinoma sensitive RP-3500 Preclinical - Cell culture Actionable In a preclinical study, RP-3500 inhibited viability in a non-small cell lung cancer cell line harboring ATM Q1919P in culture (PMID: 34911817). 34911817