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Therapy Name RP-3500
Synonyms
Therapy Description

RP-3500 binds to and inhibits ATR, which may lead to decreased downstream signaling and inhibition of tumor growth (PMID: 34911817).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
RP-3500 RP 3500|RP3500|Camonsertib ATR Inhibitor 16 RP-3500 binds to and inhibits ATR, which may lead to decreased downstream signaling and inhibition of tumor growth (PMID: 34911817).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C inact mut ovarian cancer predicted - sensitive RP-3500 Case Reports/Case Series Actionable In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a partial response with complete resolution of the target lesion at 19 weeks in a patient with ovarian cancer harboring a RAD51C inactivating mutation (PMID: 37277454; NCT04497116). 37277454
ATM Q1919P lung non-small cell carcinoma sensitive RP-3500 Preclinical - Cell culture Actionable In a preclinical study, RP-3500 inhibited viability in a non-small cell lung cancer cell line harboring ATM Q1919P in culture (PMID: 34911817). 34911817
ATM loss stomach cancer sensitive RP-3500 Preclinical - Pdx Actionable In a preclinical study, RP-3500 resulted in complete tumor regression in a gastric cancer patient-derived xenograft (PDX) model with biallelic loss of ATM (PMID: 34911817). 34911817
ATM Q628Pfs*7 ATM I1581Nfs*5 ATM A2843V colon adenocarcinoma sensitive RP-3500 Preclinical - Cell line xenograft Actionable In a preclinical study, RP-3500 inhibited viability in a colon adenocarcinoma cell line harboring ATM Q628Pfs*7, ATM I1581Nfs*5, and ATM A2843V in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 34911817). 34911817
ATM inact mut Advanced Solid Tumor predicted - sensitive RP-3500 Phase Ib/II Actionable In a Phase I/II trial (TRESR), RP-3500 treatment resulted in an overall response rate (ORR) of 15% (7/46) and clinical benefit rate of 48% (22/46) in advanced solid tumor patients with ATM inactivation, an ORR of 18% (5/28) with germline ATM loss of function (LOF) mutations, and an ORR of 13% (2/15) with somatic ATM LOF mutations, with benefit in patients with non-small cell lung (n=2), bile duct (3/4), colorectal (3/6), and prostate (4/8) cancers (Ann Oncol (2024) 35 (Suppl_2): S496; NCT04497116). detail...
ATM inact mut lung non-small cell carcinoma predicted - sensitive RP-3500 Case Reports/Case Series Actionable In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a partial response after 37 weeks of treatment in a patient with advanced non-small cell lung cancer harboring germline biallelic ATM inactivation (PMID: 37277454; NCT04497116). 37277454
ATM R2832C mantle cell lymphoma sensitive RP-3500 Preclinical - Cell line xenograft Actionable In a preclinical study, RP-3500 inhibited viability in a mantle cell lymphoma cell line harboring ATM R2832C in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 34911817). 34911817
ATM R3008H prostate cancer predicted - sensitive RP-3500 Case Reports/Case Series Actionable In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a 29% tumor reduction in a castration-resistant prostate cancer patient harboring ATM R3008H, who remained on treatment for more than 61 weeks (PMID: 37277454; NCT04497116). 37277454
ATM inact mut pancreatic cancer predicted - sensitive RP-3500 Case Reports/Case Series Actionable In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a partial response at week 54 in a patient with advanced pancreatic cancer harboring a germline ATM frameshift mutation (PMID: 37277454; NCT04497116). 37277454

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05566574 Phase Ib/II RP-3500 A Study of RP-3500 in Combination With Standard Radiation Therapy in People With Solid Tumor Cancer Recruiting USA 0
NCT04497116 Phase Ib/II RP-3500 + Talazoparib RP-3500 Study of RP-3500 in Advanced Solid Tumors Recruiting USA | GBR | DNK | CAN 0
NCT04589845 Phase II Alectinib Divarasib Entrectinib RP-3500 Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study Recruiting USA | POL | NZL | NLD | ITA | ISR | GBR | FRA | ESP | DNK | DEU | CHE | CAN | BRA | BEL | AUS 10


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