PDGFRB A6V
Gene Variant Detail

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Gene PDGFRB
Variant A6V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PDGFRB A6V lies within the signal peptide region of the Pdgfrb protein (UniProt.org). A6V has been identified in the scientific literature (PMID: 25336117), but has not been biochemically characterized and therefore, its effect on Pdgfrb protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

PDGFRB mutant PDGFRB A6V

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Transcript NM_002609.4
gDNA chr5:g.150137031G>A
cDNA c.17C>T
Protein p.A6V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002609.4 chr5:g.150137031G>A c.17C>T p.A6V RefSeq GRCh38/hg38
NM_001355017.2 chr5:g.150134847G>A c.17C>T p.A6V RefSeq GRCh38/hg38
NM_002609.3 chr5:g.150137031G>A c.17C>T p.A6V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRB A6V colorectal cancer predicted - sensitive Regorafenib Case Reports/Case Series Actionable In a clinical case study, a patient with metastatic colorectal cancer harboring germline PDGFRB A6V demonstrated a partial morphological and metabolic response after 8 weeks of treatment with Stivarga (regorafenib) and remained in partial remission with sustained clinical improvement for at least 9 months from the start of treatment (PMID: 25336117). 25336117