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Gene BRAF
Variant G469K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G469K is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469K has been identified in the scientific literature (PMID: 29325942, PMID: 30348504, PMID: 31015314), but has not been biochemically characterized, and therefore, its effect on Braf protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G469X BRAF G469K

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Transcript NM_004333.6
gDNA chr7:g.140781602_140781603delGGinsAA
cDNA c.1405_1406delGGinsAA
Protein p.G469K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.2 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140781611_140781612delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140778000_140778001delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781602_140781603delGGinsAA c.1405_1406delGGinsAA p.G469K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
BRAF G469K unknown