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Gene BRAF
Variant S602A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF S602A lies within the protein kinase domain of the Braf protein (UniProt.org). S602A (reported as S601A) retains binding to 14-3-3, Hsp90, and Mek, but results in reduced kinase activity in response to stimuli in cultured cells (PMID: 11032810), and therefore, is predicted to lead to a loss of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF S602A

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Transcript NM_004333.6
gDNA chr7:g.140753331A>C
cDNA c.1804T>G
Protein p.S602A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140753331A>C c.1804T>G p.S602A RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140753295A>C c.1804T>G p.S602A RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753331A>C c.1804T>G p.S602A RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753331A>C c.1804T>G p.S602A RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753331A>C c.1804T>G p.S602A RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753331A>C c.1804T>G p.S602A RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753331A>C c.1804T>G p.S602A RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries