Gene Variant Detail

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Gene ALK
Variant C1097A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions ALK C1097A lies within the cytoplasmic domain of the Alk protein (UniProt.org). C1097A is not activating in an in vitro assay and is weakly transforming in culture in one study (PMID: 33674381) but in another study is not transforming in culture, does not lead to ligand-independent kinase activity, and retains functional kinase activity upon ligand binding in culture (PMID: 29084134), and therefore, is predicted to have no effect on Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK C1097A

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Transcript NM_004304.5
gDNA chr2:g.29223411_29223412delTGinsGC
cDNA c.3289_3290delTGinsGC
Protein p.C1097A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29223411_29223412delTGinsGC c.3289_3290delTGinsGC p.C1097A RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29223411_29223412delTGinsGC c.3289_3290delTGinsGC p.C1097A RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References