Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene ALK
Variant C1097A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions ALK C1097A lies within the cytoplasmic domain of the Alk protein (UniProt.org). C1097A is not activating in an in vitro assay and is weakly transforming in culture in one study (PMID: 33674381) but in another study is not transforming in culture, does not lead to ligand-independent kinase activity, and retains functional kinase activity upon ligand binding in culture (PMID: 29084134), and therefore, is predicted to have no effect on Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK C1097A

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_004304.5
gDNA chr2:g.29223411_29223412delTGinsGC
cDNA c.3289_3290delTGinsGC
Protein p.C1097A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29223411_29223412delTGinsGC c.3289_3290delTGinsGC p.C1097A RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29223411_29223412delTGinsGC c.3289_3290delTGinsGC p.C1097A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries