ALK D1163N
Gene Variant Detail

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Gene ALK
Variant D1163N
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ALK D1163N lies within the protein kinase domain of the Alk protein (UniProt.org). D1163N is not transforming in cultured cells but is activating in an in vitro assay (PMID: 33674381), and therefore, is predicted to lead to a gain of Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK D1163N

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Transcript NM_004304.5
gDNA chr2:g.29222372C>T
cDNA c.3487G>A
Protein p.D1163N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29222372C>T c.3487G>A p.D1163N RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222372C>T c.3487G>A p.D1163N RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References