ALK I1170V
Gene Variant Detail

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Gene ALK
Variant I1170V
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ALK I1170V lies within the protein kinase domain of the Alk protein (UniProt.org). I1170V is not transforming in cultured cells but is activating in an in vitro assay (PMID: 33674381), and therefore, is predicted to lead to a gain of Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK I1170V

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Transcript NM_004304.5
gDNA chr2:g.29222351T>C
cDNA c.3508A>G
Protein p.I1170V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29222351T>C c.3508A>G p.I1170V RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222351T>C c.3508A>G p.I1170V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References