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Gene ALK
Variant Y1278E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK Y1278E lies within the protein kinase domain of the Alk protein (UniProt.org). Y1278E is not activating in an in vitro assay and is not transforming in culture (PMID: 33674381, PMID: 25517749), but has not been fully biochemically characterized and therefore, its effect on Alk protein function is unknown.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK Y1278E

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Transcript NM_004304.5
gDNA chr2:g.29209788_29209790delTACinsGAG
cDNA c.3832_3834delTACinsGAG
Protein p.Y1278E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29209788_29209790delTACinsGAG c.3832_3834delTACinsGAG p.Y1278E RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29209788_29209790delTACinsGAG c.3832_3834delTACinsGAG p.Y1278E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References