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Gene TSC1
Variant F188S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TSC1 F188S does not lie within any known functional domains of the Tsc1 protein (UniProt.org). F188S has been identified in the scientific literature (PMID: 35171658), but has not been biochemically characterized and therefore, its effect on Tsc1 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

TSC1 mutant TSC1 F188S

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Transcript NM_000368.5
gDNA chr9:g.132921919A>G
cDNA c.563T>C
Protein p.F188S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011518979.3 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406596.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_000368.5 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406592.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406603.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406607.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406594.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
XM_011518979.2 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406598.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406605.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
XM_017015097.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_000368.4 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406608.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406600.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406604.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001162426.2 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406599.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
XM_005272211.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
XM_006717271.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406593.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406609.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
XM_017015096.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
XM_017015098.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406597.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406595.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406602.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406601.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001162426.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38
NM_001406606.1 chr9:g.132921919A>G c.563T>C p.F188S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References