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Gene ALK
Variant G1201R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK G1201R lies within the protein kinase domain of the Alk protein (UniProt.org). The functional effect of G1201R is conflicting as it is transforming (PMID: 33674381), but results in impaired kinase activity in cultured cells (PMID: 33674381, PMID: 28030793), and therefore, its effect on Alk protein function is unknown.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK G1201R

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Transcript NM_004304.5
gDNA chr2:g.29220750C>T
cDNA c.3601G>A
Protein p.G1201R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220750C>T c.3601G>A p.G1201R RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220750C>T c.3601G>A p.G1201R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References