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RET K666N - Gene Variant Detail

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Gene RET
Variant K666N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET K666N lies within the cytoplasmic domain of the Ret protein (UniProt.org). K666N results in increased Ret autophosphorylation and Erk phosphorylation and is transforming in culture (PMID: 20103606).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET K666N

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Transcript NM_020975.6
gDNA chr10:g.43114598G>C
cDNA c.1998G>C
Protein p.K666N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43123764G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43123764G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43123764G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43123764G>C c.1998G>C p.K666N RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114598G>C c.1998G>C p.K666N RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries