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Gene RET
Variant L629_L633del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET L629_L633del results in the deletion of five amino acids in the extracellular domain of the Ret protein from amino acids 629 to 633 (UniProt.org). L629_L633del has been identified in the scientific literature (PMID: 28676824), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET L629_L633del

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Transcript NM_020975.6
gDNA chr10:g.43114485_43114499del15
cDNA c.1885_1899del15
Protein p.L629_L633del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43114485_43114499del15 c.1885_1899del15 p.L629_L633del RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114485_43114499del15 c.1885_1899del15 p.L629_L633del RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114485_43114499del15 c.1885_1899del15 p.L629_L633del RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114485_43114499del15 c.1885_1899del15 p.L629_L633del RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114485_43114499del15 c.1885_1899del15 p.L629_L633del RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114485_43114499del15 c.1885_1899del15 p.L629_L633del RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114485_43114499del15 c.1885_1899del15 p.L629_L633del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References