BTK del
Gene Variant Detail

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Gene BTK
Variant del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions BTK del indicates a deletion of the BTK gene.
Associated Drug Resistance
Category Variants Paths

BTK mutant BTK inact mut BTK del

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK del mantle cell lymphoma predicted - resistant Edralbrutinib Preclinical - Cell culture Actionable In a preclinical study, Edralbrutinib (TG-1701) treatment resulted in reduced cell growth inhibition in a mantle cell lymphoma cell line with BTK knockout compared to the parental wild-type BTK cell line in culture (PMID: 34551904). 34551904