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BRAF L584P - Gene Variant Detail

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Gene BRAF
Variant L584P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF L584P lies within the protein kinase domain of the Braf protein (UniProt.org). L584P has been identified in the scientific literature (PMID: 31569065), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF L584P

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Transcript NM_004333.6
gDNA chr7:g.140753384A>G
cDNA c.1751T>C
Protein p.L584P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140753384A>G c.1751T>C p.L584P RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753384A>G c.1751T>C p.L584P RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753384A>G c.1751T>C p.L584P RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140753282_140753283delTTinsCC c.1750_1751delTTinsCC p.L584P RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753384A>G c.1751T>C p.L584P RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753384A>G c.1751T>C p.L584P RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753384A>G c.1751T>C p.L584P RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G469A BRAF L584P melanoma predicted - sensitive Dabrafenib + Trametinib Case Reports/Case Series Actionable In a clinical case study, Mekinist (trametinib) and Tafinlar (dabrafenib) combination treatment resulted in decrease in metastatic lesions and a partial response with 94% reduction at three months and continued metabolic response at six months in a patient with metastatic melanoma harboring BRAF G469A and BRAF L584P (PMID: 31569065). 31569065