BRAF K601E
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene BRAF
Variant K601E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF K601E lies within the activation segment in the kinase domain of the Braf protein (PMID: 15343278). K601E results in increased Braf kinase activity and downstream activation of MEK and ERK in cell culture (PMID: 22798288, PMID: 28783719, PMID: 32059434), and induces cell proliferation and cell viability in culture (PMID: 29533785, PMID: 18697864).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF K601E

BRAF mutant BRAF K601X BRAF K601E

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_004333.6
gDNA chr7:g.140753334T>C
cDNA c.1801A>G
Protein p.K601E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753334T>C c.1801A>G p.K601E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF K601E gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF S363F BRAF K601E
BRAF K601E MAP2K1 V211D