Gene Variant Detail

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Gene RET
Variant R177W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET R177W lies within the cadherin domain of the Ret protein (UniProt.org). R177W has been identified in sequencing studies (PMID: 34741450, PMID: 32284345), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET R177W

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Transcript NM_020975.6
gDNA chr10:g.43102533C>T
cDNA c.529C>T
Protein p.R177W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43102533C>T c.529C>T p.R177W RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References