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Gene RET
Variant V485L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET V485L lies within the extracellular domain of the Ret protein (UniProt.org). V485L has been identified in sequencing studies (PMID: 34741450), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET V485L

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Transcript NM_020975.6
gDNA chr10:g.43111396G>C
cDNA c.1453G>C
Protein p.V485L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43116662G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43111396G>C c.1453G>C p.V485L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References