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Gene | RET |
Variant | K662M |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RET K662M lies within the cytoplasmic domain of the Ret protein (UniProt.org). K662M has been identified in sequencing studies (PMID: 34741450, PMID: 32284345), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, May 2025). |
Associated Drug Resistance | |
Category Variants Paths |
RET mutant RET K662M |
Transcript | NM_020975.6 |
gDNA | chr10:g.43114585A>T |
cDNA | c.1985A>T |
Protein | p.K662M |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |