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Gene APC
Variant Q1406*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC Q1406* results in a premature truncation of the Apc protein at amino acid 1406 of 2843 (UniProt.org). Q1406* has not been characterized, however, due to the effects of other truncation mutations downstream of Q1406 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC Q1406*

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Transcript NM_000038.6
gDNA chr5:g.112839810C>T
cDNA c.4216C>T
Protein p.Q1406*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407450.1 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001354900.2 chr5:g.112839933C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001407446.1 chr5:g.112839726C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001354900.1 chr5:g.112839933C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_000038 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839810C>T c.4216C>T p.Q1406* RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC Q1406* colorectal cancer predicted - sensitive XAV939 Preclinical Actionable In a preclinical study, XAV939 treatment inhibited growth of mouse intestinal organoids expressing APC Q1045* (corresponding to Q1046* in human) in culture (PMID: 31337618). 31337618
APC Q1406* colorectal cancer predicted - sensitive G007-LK Preclinical Actionable In a preclinical study, G007-LK treatment altered gene expression pattern and inhibited growth of mouse intestinal organoids expressing APC Q1045* (corresponding to Q1046* in human) in culture (PMID: 31337618). 31337618
APC Q1406* colorectal cancer predicted - sensitive NVP-TNKS656 Preclinical Actionable In a preclinical study, NVP-TNKS656 treatment inhibited growth of mouse intestinal organoids expressing APC Q1045* (corresponding to Q1046* in human) in culture (PMID: 31337618). 31337618