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Therapy Name	XAV939
Synonyms
Therapy Description	XAV939 selectively inhibits Wnt/beta-catenin-mediated signaling by inhibiting tankyrase1/2, thus stabilizing axin and stimulating beta-catenin degradation (PMID: 19759537, PMID: 32681294).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
XAV939		XAV-939	Tankyrase Inhibitor 11	XAV939 selectively inhibits Wnt/beta-catenin-mediated signaling by inhibiting tankyrase1/2, thus stabilizing axin and stimulating beta-catenin degradation (PMID: 19759537, PMID: 32681294).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
APC E853* APC T1556fs	colorectal cancer	resistant	XAV939	Preclinical - Cell culture	Actionable	In a preclinical study, a colorectal cancer cell line harboring APC E853* and APC T1556fs (reported as APC T1556fs*3) demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with XAV939 in culture (PMID: 28179481).	28179481
APC L665* APC R1450*	colorectal cancer	sensitive	XAV939	Preclinical - Cell culture	Actionable	In a preclinical study, a colorectal cancer cell line harboring APC L665* and APC R1450* demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with XAV939 in culture (PMID: 28179481).	28179481
APC N1819fs APC wild-type	colorectal cancer	resistant	XAV939	Preclinical - Cell culture	Actionable	In a preclinical study, a colorectal cancer cell line harboring APC N1819fs (reported as N1819fs*7) and a wild-type copy of APC demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with XAV939 in culture (PMID: 28179481).	28179481
APC S1197* APC S1278*	colorectal cancer	sensitive	XAV939	Preclinical - Cell culture	Actionable	In a preclinical study, XAV939 inhibited growth of a colorectal cancer cell line harboring APC S1197* and APC S1278* in culture (PMID: 28179481).	28179481
APC S811*	colorectal cancer	sensitive	XAV939	Preclinical - Cell culture	Actionable	In a preclinical study, XAV939 inhibited growth of a colorectal cancer cell line harboring APC S811* in culture (PMID: 28179481).	28179481
APC inact mut	colorectal cancer	sensitive	XAV939	Preclinical	Actionable	In a preclinical study, XAV939 inhibited growth of colorectal cancer cells harboring APC inactivating mutations in culture (PMID: 19759537).	19759537
APC Q1406*	colorectal cancer	predicted - sensitive	XAV939	Preclinical	Actionable	In a preclinical study, XAV939 treatment inhibited growth of mouse intestinal organoids expressing APC Q1045* (corresponding to Q1046* in human) in culture (PMID: 31337618).	31337618
APC Q886*	colorectal cancer	predicted - resistant	XAV939	Preclinical	Actionable	In a preclinical study, XAV939 treatment did not affect growth of mouse intestinal organoids expressing APC Q884* (corresponding to Q886* in human) in culture (PMID: 31337618).	31337618

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