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Gene RET
Variant E632_A639delinsHR
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET E632_A639delinsHR results in a deletion of eight amino acids in the extracellular domain of the Ret protein from amino acids 632 to 639, combined with the insertion of a histidine (H) and an arginine (R) at the same site (UniProt.org). E632_A639delinsHR has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET E632_A639delinsHR

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Transcript NM_020975.6
gDNA chr10:g.43114494_43114517delinsCATAGG
cDNA c.1894_1917delinsCATAGG
Protein p.E632_A639delinsHR
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114494_43114517delinsCATAGG c.1894_1917delinsCATAGG p.E632_A639delinsHR RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References