Gene Variant Detail

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Gene RET
Variant E632_C634del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET E632_C634del results in the deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 632 to 634 (UniProt.org). E632_C634del has been identified in the scientific literature (PMID: 35616103, PMID: 31605946), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET E632_C634del

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Transcript NM_020975.6
gDNA chr10:g.43114494_43114502delGAGCTGTGC
cDNA c.1894_1902delGAGCTGTGC
Protein p.E632_C634delELC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406774.1 chr10:g.43119558_43119566delCCAAATACG c.1895_1903delCCAAATACG p.A632_Y634delAKY RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43114629_43114637delCGGAGGCCC c.1894_1902delCGGAGGCCC p.R632_P634delRRP RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43114624_43114632delCCTTCCGGA c.1895_1903delCCTTCCGGA p.T632_R634delTFR RefSeq GRCh38/hg38
NM_001406791.1 chr10:g.43126734_43126742delCATGCATTT c.1894_1902delCATGCATTT p.H632_F634delHAF RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634del RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43114629_43114637delCGGAGGCCC c.1894_1902delCGGAGGCCC p.R632_P634delRRP RefSeq GRCh38/hg38
NM_001406790.1 chr10:g.43126614_43126622delCTGATTTAT c.1894_1902delCTGATTTAT p.L632_Y634delLIY RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43122006_43122014delCAAAGTGAT c.1894_1902delCAAAGTGAT p.Q632_D634delQSD RefSeq GRCh38/hg38
NM_001406784.1 chr10:g.43123755_43123763delCCTTCTGAA c.1896_1904delCCTTCTGAA p.N632_L634delNLL RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634del RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43118378_43118386delGCCTCCCCG c.1894_1902delGCCTCCCCG p.A632_P634delASP RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634delELC RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43116629_43116637delAAAACTCTA c.1894_1902delAAAACTCTA p.K632_L634delKTL RefSeq GRCh38/hg38
NM_001406775.1 chr10:g.43120094_43120102delACTTGGCAG c.1895_1903delACTTGGCAG p.D632_A634delDLA RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43116605_43116613delCCTCGGAAG c.1894_1902delCCTCGGAAG p.P632_K634delPRK RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43114624_43114632delCCTTCCGGA c.1895_1903delCCTTCCGGA p.T632_R634delTFR RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634delELC RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634delELC RefSeq GRCh38/hg38
NM_001406788.1 chr10:g.43126614_43126622delCTGATTTAT c.1894_1902delCTGATTTAT p.L632_Y634delLIY RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43116629_43116637delAAAACTCTA c.1894_1902delAAAACTCTA p.K632_L634delKTL RefSeq GRCh38/hg38
NM_001406789.1 chr10:g.43126614_43126622delCTGATTTAT c.1894_1902delCTGATTTAT p.L632_Y634delLIY RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43118420_43118428delGTCCTGAAG c.1894_1902delGTCCTGAAG p.V632_K634delVLK RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634delELC RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43123789_43123797delGACAACTGC c.1894_1902delGACAACTGC p.D632_C634delDNC RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43122006_43122014delCAAAGTGAT c.1894_1902delCAAAGTGAT p.Q632_D634delQSD RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634delELC RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43114624_43114632delCCTTCCGGA c.1895_1903delCCTTCCGGA p.T632_R634delTFR RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43123795_43123803delTGCAGCGAG c.1894_1902delTGCAGCGAG p.C632_E634delCSE RefSeq GRCh38/hg38
NM_001406778.1 chr10:g.43120094_43120102delACTTGGCAG c.1895_1903delACTTGGCAG p.D632_A634delDLA RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114494_43114502delGAGCTGTGC c.1894_1902delGAGCTGTGC p.E632_C634delELC RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43122006_43122014delCAAAGTGAT c.1894_1902delCAAAGTGAT p.Q632_D634delQSD RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43123782_43123790delGAGGCCAGA c.1896_1904delGAGGCCAGA p.E632_P634delERP RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43120094_43120102delACTTGGCAG c.1895_1903delACTTGGCAG p.D632_A634delDLA RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43120129_43120137delCGGAAGATG c.1894_1902delCGGAAGATG p.R632_M634delRKM RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43118378_43118386delGCCTCCCCG c.1894_1902delGCCTCCCCG p.A632_P634delASP RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43122006_43122014delCAAAGTGAT c.1894_1902delCAAAGTGAT p.Q632_D634delQSD RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43123789_43123797delGACAACTGC c.1894_1902delGACAACTGC p.D632_C634delDNC RefSeq GRCh38/hg38
NM_001406776.1 chr10:g.43120094_43120102delACTTGGCAG c.1895_1903delACTTGGCAG p.D632_A634delDLA RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43118420_43118428delGTCCTGAAG c.1894_1902delGTCCTGAAG p.V632_K634delVLK RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43116629_43116637delAAAACTCTA c.1894_1902delAAAACTCTA p.K632_L634delKTL RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries